What is Betamethasone (Frenaler Cort)?

What is Betamethasone (Frenaler Cort)?

Betamethasone (Frenaler Cort) sodium phosphate and Betamethasone (Frenaler Cort) acetate combination injection provides relief for inflamed areas of the body. It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, lung or breathing problems, blood or bone marrow problems, eye or vision problems, lupus, serious skin conditions, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis. Betamethasone (Frenaler Cort) sodium phosphate and Betamethasone (Frenaler Cort) acetate combination is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic reactions.

Betamethasone (Frenaler Cort) sodium phosphate and Betamethasone (Frenaler Cort) acetate is to be given only by or under the direct supervision of your doctor.

Betamethasone (Frenaler Cort) Suspension is indicated for the treatment of acute and chronic corticosteroid-responsive disorders. Corticosteroid hormone therapy is an adjunct to, and not a replacement for conventional therapy.

Musculoskeletal and Soft Tissue Conditions: Rheumatoid arthritis, osteoarthritis, bursitis, ankylosing spondylitis, epicondylitis, radiculitis, coccydynia, sciatica, lumbago, torticollis, ganglion cyst, exostasis and fasciitis.

Allergic Conditions: Chronic bronchial asthma (including adjunctive therapy for status asthmaticus), hay fever, angioneurotic edema, allergic bronchitis, seasonal or perennial allergic rhinitis, drug reactions, serum sickness and insect bites.

Dermatologic Conditions: Atopic dermatitis (nummular eczema), neurodermatitis (circumscribed lichen simplex), contact dermatitis, severe solar dermatitis, urticaria, hypertrophic lichen planus, necrobiosis lipoidica diabeticorum, alopecia areata, discoid lupus erythematosus, psoriasis, keloids, pemphigus, dermatitis herpetiformis and cystic acne.

Collagen Diseases: Disseminated lupus erythematosus, scleroderma, dermatomyositis, periarteritis nodosa.

Neoplastic Diseases: Palliative management of leukemias and lymphomas in adults; acute leukemia of childhood.

Other Conditions: Adrenogenital syndrome, ulcerative colitis, regional ileitis, sprue, podiatric conditions (bursitis under heloma durum, hallux rigidus, digiti quinti varus), affections requiring subconjunctival injection, corticosteroid-responsive blood dyscrasias, nephritis and nephrotic syndrome.

Frenaler Cort sodium phosphate and Betamethasone
Frenaler Cort sodium phosphate and Betamethasone

Primary or secondary adrenocortical insufficiency may be treated with Betamethasone (Frenaler Cort) Suspension but should be supplemented with mineralocorticosteroids, if applicable.

Betamethasone (Frenaler Cort) Suspension is recommended for intramuscular injection in conditions responsive to systemic corticosteroids; injection directly into the affected soft tissues where indicated; intra-articular and periarticular injection in arthritides; intralesional injection in various dermatologic conditions; and local injection in certain inflammatory and cystic disorders of the foot.

HOW SHOULD I USE BETAMETHASONE (FRENALER CORT)?

Use Betamethasone (Frenaler Cort) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Betamethasone (Frenaler Cort) by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Use the dropper that comes with Betamethasone (Frenaler Cort) to measure your dose. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If Betamethasone (Frenaler Cort) needs to be stopped (or if a different medicine is added to therapy) by your doctor, this will be done gradually. The risk of side effects may be increased if Betamethasone (Frenaler Cort) is suddenly stopped.
  • If you miss a dose of Betamethasone (Frenaler Cort), take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Betamethasone (Frenaler Cort).

This medication is used to treat a variety of skin conditions (e.g., eczema, dermatitis, allergies, rash). Betamethasone (Frenaler Cort) reduces the swelling, itching, and redness that can occur in these types of conditions. This medication is a medium-strength corticosteroid.

How to use Betamethasone (Frenaler Cort) topical

Use this medication on the skin only. However, do not use it on the face, groin, or underarms unless directed to do so by your doctor.

Wash and dry your hands before using. Clean and dry the affected area. Apply a thin film of medication to the affected area and gently rub in, usually 1-3 times daily or as directed by your doctor. Do not bandage, cover, or wrap the area unless directed to do so by your doctor. If used in the diaper area on an infant, do not use tight-fitting diapers or plastic pants.

After applying the medication, wash your hands unless you are using this medication to treat the hands. When applying this medication near the eyes, avoid getting it in the eyes because this may worsen or cause glaucoma. Also, avoid getting this medication in the nose or mouth. If you get the medication in these areas, rinse with plenty of water.

Use this medication only for the condition for which it was prescribed. Do not use it for longer than prescribed.

Inform your doctor if your condition persists or worsens after 2 weeks.

Each gram of Betamethasone (Frenaler Cort) (Betamethasone (Frenaler Cort)*) Cream* contains: 640 mcg Betamethasone (Frenaler Cort) dipropionate (equivalent to 500 mcg Betamethasone (Frenaler Cort)).

Each gram of Betamethasone (Frenaler Cort) (Betamethasone (Frenaler Cort)*) Ointment* contains: 640 mcg Betamethasone (Frenaler Cort) dipropionate (equivalent to 500 mcg Betamethasone (Frenaler Cort)).

Betamethasone (Frenaler Cort) (Betamethasone (Frenaler Cort)*) Cream and Ointment contain Betamethasone (Frenaler Cort) dipropionate, a synthetic corticosteroid with anti-inflammatory activity to be administered topically.

Betamethasone (Frenaler Cort) dipropionate is a white to creamy white odorless crystalline powder insoluble in water; freely soluble in acetone and in chloroform; sparingly soluble in alcohol. It has a molecular weight of 504.16 and the empirical formula C28H37FO7; a chemical name of 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione,17,21-dipropionate.

BETAMETHASONE (FRENALER CORT) DOSAGE

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Kit, Injection:

Pod-Care 100C: Betamethasone (Frenaler Cort) sodium phosphate 3 mg and Betamethasone (Frenaler Cort) acetate 3 mg per 1 mL [contains benzalkonium chloride, disodium edta]

ReadySharp Betamethasone (Frenaler Cort): Betamethasone (Frenaler Cort) sodium phosphate 3 mg and Betamethasone (Frenaler Cort) acetate 3 mg per 1 mL [contains benzalkonium chloride, disodium edta]

Suspension, Injection:

Betamethasone (Frenaler Cort): Betamethasone (Frenaler Cort) sodium phosphate 3 mg and Betamethasone (Frenaler Cort) acetate 3 mg per 1 mL (5 mL) [contains benzalkonium chloride, edetate disodium]

Generic: Betamethasone (Frenaler Cort) sodium phosphate 3 mg and Betamethasone (Frenaler Cort) acetate 3 mg per 1 mL (5 mL)

Dosing: Adult

Note: Dosages expressed as combined amount of Betamethasone (Frenaler Cort) sodium phosphate and Betamethasone (Frenaler Cort) acetate; 1 mg is equivalent to Betamethasone (Frenaler Cort) sodium phosphate 0.5 mg and Betamethasone (Frenaler Cort) acetate 0.5 mg.

Usual dosage range: IM: Initial: 0.25 to 9 mg/day (based on severity of disease and patient response).

Indication-specific dosing:

Antenatal fetal maturation (off-label use): IM: 12 mg every 24 hours for a total of 2 doses (ACOG 171 2016). A single course of Betamethasone (Frenaler Cort) is recommended for women between 24 and 34 weeks of gestation, including those with ruptured membranes or multiple gestations, who are at risk of delivering within 7 days. A single course may be appropriate in some women beginning at 23 weeks gestation or late preterm (between 34 0/7 weeks and 36 6/7 weeks gestation). A single repeat course may be considered in some women with pregnancies less than 34 weeks gestation at risk for delivery within 7 days and who had a course of antenatal corticosteroids >14 days prior (ACOG 171 2016; ACOG 713 2017, ACOG 188 2018).

Bursitis (other than of foot): Intra-articular: 3 to 6 mg (0.5 to 1 mL) for one dose; additional injections may be required for acute exacerbations or chronic conditions; generally, injections should be separated by a minimum of 4 to 6 weeks and limited to ≤4 injections per year. If symptoms are not improved after 1 or 2 injections, additional injections are unlikely to provide benefit (Cardone 2002); following resolution of acute episodes, reduced doses may be warranted for chronic conditions.

Dermatologic conditions: Intradermal: 1.2 mg/cm displayed a good or excellent response (Chowdri, 1994). Another trial (n=25, age range: 7 weeks to 2 years) used lower doses of 3 to 12 mg (in combination with triamcinolone); 16 patients experienced a marked response (Kushner, 1985).

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